A REVIEW ON ANGIOGENESIS IN TUMOR

ANGIOGENESIS is a necessary process in many physiological and pathological events such as TUMOR growth. Therefore ANGIOGENESIS therapy can be a strategy to cancer treatment. It is important to identify different aspects of TUMOR’s ANGIOGENESIS. Formation of functional vessels within TUMORs is essential for its growth and progression. The induction of new blood vessel growth by TUMORs is mediated through different molecules. A balance between pro-angiogenic and anti-angiogenic growth factors strictly control the process. This fact has led to design of therapeutic agents against TUMOR ANGIOGENESIS. Recently, endogenous (such as interleukin -8) and exogenous ANGIOGENESIS inhibitors (such as: Avastin) have been described. Furthermore because of the low mutagenic potential of endothelial cells, TUMOR’s vessel do not show resistance to the effects of many of these compounds. In addition, it is recognized that anti-ANGIOGENESIS and anti-cancer TUMORs can be more effective by combination of factors than the use of either alone. This article would review different aspects of ANGIOGENESIS in TUMORs. Since TUMOR growth is dependent on the DEVELOPMENT of blood vessels in the TUMOR, inhibition of ANGIOGENESIS maybe considered an appropriate treatment for cancer.