COMPARISON THE EFFECT OF MOVENTO, A CHEMICAL PESTICIDE, WITH CHITOSAN, A BIOLOGIC PESTICIDE, ON FEMALE REPRODUCTIVE SYSTEM IN BALB/C MICE

 Chemical pesticides possess toxic and destructive impacts on the reproductive system and disrupt endocrine function. In this experimental study, the effect of movento, as a chemical pesticide, was investigated in comparison with chitosan, a biological pesticide, on the female reproductive systemin vivo. In this study, 56 mice were randomly dived into 7 groups including control and experimental groups treated with movento and chitosan. After a 21-day treatment, mice were killed and their ovaries and blood being collected. In addition, the samples were fixed and stained with H & E method. The results exhibited that treatment with 2.5 and 5 mg/kg chitosan had no significant effect on the number and diameter of primary, secondary and antral FOLLICLEs, while these items were significantly reduced in 10 mg/kg chitosan group and all movento-treated groups as well. In addition, the level of SEXUAL HORMONEs, such as estradiol, FSH and LH, was decreased in 10 mg/kg chitosan group and all movento-treated groups in comparison with the control group.The findings showed that movento affected the SEXUAL HORMONE levels, ovary and OVARIAN FOLLICLE structure and induced abnormality in female reproductive system, while chitosan, as a biological pesticide, should be used due to its minimum effects on female reproductive system.